Nabota 100 Units

Description

Nabota 100 Units

(Clostridium botulinum toxin)

Overview

Nabota, developed through five years of in-house research and development by Daewoong Pharmaceutical, is a high-quality product with high purity produced using the latest patented purification method. It is not a genetically modified variant but a natural type of Botulinum Toxin Type A.

Core Technologies:

• Patented production technology (Patent registered KR1339349)
• Product with reduced impurities
• Product expanding globally, including advanced countries such as the United States and Europe (Overseas expansion)

Efficacy and Effects:

Temporary improvement of moderate to severe glabellar lines associated with the activity of the corrugator muscle and/or procerus muscle in adults aged 20 to 65 years old.

Key Ingredient:

Clostridium botulinum toxin type A (referred to as ‘A-hemagglutinin-complex’) 100 units

Physical Description:

A white or slightly yellowish lyophilized powder contained in a colorless transparent vial, which forms a clear and transparent solution when dissolved in physiological saline solution.

Category:

Prescription Drug (ETC)

Glabellar Wrinkles

• Dilute the medication with sterile, preservative-free saline to a concentration of 100U/2.5 mL (4U/0.1 mL). Inject 0.1 mL into each of the five areas, including two sites in each corrugator muscle and one site in the procerus muscle, using a 30-gauge needle. A total of 20U should be injected.
• To reduce complications such as eyelid ptosis, avoid injections near the levator palpebrae superioris muscle, especially in patients with prominent brow depressor muscles. When injecting the inner corrugator and central brow, inject at least 1cm away from the orbital rim.
• Exercise caution to avoid vascular injection and prevent extravasation beneath the orbital margin by firmly placing the thumb or forefinger below the orbital rim before injection. Keep the needle oriented upward during injection and ensure accurate dosing.
• The medication works by denervating the targeted muscles, including the corrugator and procerus muscles, which contribute to glabellar facial wrinkles. The effective dose depends on individual muscle anatomy, size, and function, determined through overall patient assessment.

The therapeutic effect of the medication typically lasts for approximately 3-4 months. However, frequent administration beyond the recommended interval is not advised due to lack of clinical evaluation regarding safety and efficacy.

Initial administration of botulinum toxin induces chemical denervation of the injected muscles, with increasing strength observed during the first week post-injection.

Muscle Rigidity

The precise dosage and number of injection sites depend on factors such as muscle size, location, rigidity severity, presence of localized muscle weakness, and patient response to previous treatments. Clinical improvement in muscle tension is typically observed within four weeks post-injection and can persist up to 8-12 weeks.

Dosages administered in clinical trials include:

• Biceps brachii: 100-200 U, up to 4 sites
• Flexor digitorum profundus: 15-50 U, 1-2 sites
• Flexor digitorum sublimis: 15-50 U, 1-2 sites
• Flexor carpi ulnaris: 10-50 U, 1-2 sites
• Flexor carpi radialis: 15-60 U, 1-2 sites

In clinical trials, doses did not exceed 360U and were divided among individual muscles.

Sterile 24-30 gauge needles are used for superficial muscles, while appropriate needle lengths are used for deeper muscle tissue. Electromyography guidance and nerve stimulation techniques aid in selecting injection sites.

Eyelid Spasm

For the treatment of eyelid spasms, dilute the medication as per dilution instructions and use a sterile, non-preserved 27-30 gauge needle without electromyography guidance. Administer an initial dose of 2.5U (0.1mL per site) into the medial and lateral preorbital portions of the upper eyelid and the lateral preorbital portion of the lower eyelid. If spasm obscures vision, injections into the medial brow and lateral preorbital portions of the upper eyelid are an option. For subsequent doses, up to 5U per site (up to a total of 50U) per the most recent total dose may be administered.

Safety and efficacy for eyelid spasms were evaluated for single injections over a 12-week period. Safety and efficacy for re-administration intervals have not been clinically evaluated.

Dilution Method

To reconstitute the lyophilized medication, use sterile, preservative-free saline solution. A recommended dilution is 0.9% sodium chloride injection. Add an appropriate amount of diluent to a suitable syringe. If foaming or agitation occurs, the vial is compromised, and should be discarded if the diluent does not enter the vial under vacuum. Record the date and time of reconstitution on the label and administer within 24 hours. Store the reconstituted solution refrigerated (2-8°C). The solution should be colorless, clear, and free from particulate matter. Check for foreign particles or discoloration before administration, as no preservatives are present. Avoid using a single vial for multiple patients.

[Reconstitution Table]

Caution:

This dilution is based on a volume of 0.1ml per injection. Additionally, dosage adjustment can be made based on changes in injection volume. Decrease by 50% (0.05 ml) – Increase by 50% (0.15 ml).

Storage Instructions

Store in a sealed container, refrigerated (2-8°C).

Expiration Date

36 months from the date of manufacture.

Nabota is a South Korean product to combat expression wrinkles. It is a muscle relaxant of peripheral action, an analogue of Botox. Nabota 100u is a Clostridium botulinum toxin type A. Temporarily improves glabellar lines in adults. Available in vials of 100 and 200 units. Nabota 100u toxin from South Korea From JDBIO Shop Nabota 100ui is a botulinum toxin type A that is used to correct severe wrinkles caused by uncontrolled facial muscle tone and active facial expressions. Nabota is made by Daewoong in South Korea, its botulinum toxin type A for wrinkles treatment. It is KFDA and FDA approval.

Is Nabota the same as Botox?

Nabota is a popular South Korean injectable that is marketed and FDA-approved for use in the US under the name Jeuveau. Like Botox, it’s a neuromodulator but is formulated with a slightly different form of the botulinum toxin.

Is Nabota approved by FDA?

Nabota, which was developed and manufactured by Daewoong, is the only botulinum toxin product from Korea and Asia that has received approval from the US Food and Drug Administration.